First of all, I will say that quitting smoking in any form will result in changes to your body. The cilia in your lungs begin to regrow after the first couple of days off the cigs. With this comes a new ability to clean out 20, 30, 50 years worth of gunk from smoking. Carbon monoxide leaves the body early, increasing circulation, which may cause some feeling of over heating, particularly in the body's extremities [hands, feet] Traditional smoking also increases saliva production, and in turn swallowing actions, which aids the body's digestive system. Some may experience constipation upon quitting smoking by any means, even cold turkey. Hydration is also very important for vapers. Having said all that, a small percentage of people do react to the ingredients in e-liquid, or sometimes to materials in the heating coils, or wicks. Often times, reactions to e-liquid manifest as a feeling of a "ball in the throat" as opposed to deep in the lungs from the lungs regaining cleaning capabilities. Troubleshooting is fairly straight forward, but does require either purchasing juice from one of the more up market sellers, whom allow tailoring of ratios of the constituent ingredients, or alternatively Doing It Yourself [DIY] by buying separate ingredients and mixing up juice. E-liquid, or ejuice, is made of a handful of ingredients, in differing ratios depending on the particular liquid: Propylene Glycol [PG] https://en.wikipedia.org/wiki/Propylene_glycol Vegetable Glycerine [VG] https://en.wikipedia.org/wiki/Glycerol Nicotine Flavourings [Optionally] Distilled Water If you experience symptoms of a reaction, it is possible to pinpoint which element does not agree with your system by a process of elimination. You can either mix your own liquid, leaving out 1 element each time, or buy from a liquid vendor such as Mount Baker Vapor, who allow you to choose ratios of PG and VG. This process of elimination allows you to isolate the element that is causing you irritation, or a cough. Vaping unflavoured eliquid is another option to try, should it not appear to be related to PG or VG. Within the vapouriser, the materials used in making heating coils also cause some people to react. This is commonly rendered as a scratchy throat. There are a number of coil wires available on the modern market, including kanthal, nichrome, nickel, stainless steel, and titanium. If you experience a scratchy throat, consider trialling a new type of coil, ensuring compatibility with your vapouriser hardware. Lastly, nicotine itself can irritate the throat, regardless of the level you smoked, some find liquid nicotine in vapourised form irritating to the throat. Experimenting with levels in your liquid can help with this. You may find you vape more than you smoked if your nicotine level is low, but it is certainly better than the levels of chemicals in combustion smoking. Unfortunately, there is no one size fits all, or easier way to trouble shoot. But the forums are here for vapers of all levels of experience to learn, and a thread outlining your concern in detail may aid experienced users in helping you nut out what may be causing the issue for you.